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A-Z Glossary

Table of Contents

Periorbital Cellulitis

Courtney Dryer, OD
Written byCourtney Dryer, OD
  • Last updated March 6, 2023

What is Periorbital Cellulitis?

Periorbital cellulitis is a skin and soft tissue infection around the eye, but anterior to the orbital septum. It is often called preseptal cellulitis. Periorbital cellulitis can occur at any age, but it is especially common in children. It is important to differentiate periorbital cellulitis from the less common, but more serious orbital cellulitis.

Key Takeaways

  • Periorbital cellulitis is caused by Staph and Strep bacteria.
  • It occurs most often in children due to sinusitis or trauma.
  • Periorbital cellulitis must be differentiated from the serious orbital cellulitis.
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Periorbital Cellulitis vs Orbital Cellulitis

The most common bacterial causes of periorbital cellulitis are Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes. Complications from periorbital cellulitis are rare, but it must be differentiated from orbital cellulitis, a serious condition. Orbital cellulitis is an infection of the eyeball and the tissues around it.

Orbital cellulitis has the same signs and symptoms as periorbital cellulitis because it involves the periorbital tissue, but it also results in proptosis, pain with eye movement, swelling of the conjunctiva, ophthalmoplegia, or decreased vision.

If left untreated, periorbital cellulitis may lead to orbital cellulitis and loss of vision. In extreme cases, it may extend further and result in a subperiosteal abscess, orbital abscess, cavernous sinus thrombosis, and intracranial infection such as intracerebral abscess, meningitis, empyema or abscess of the epidural or subdural space.

What Causes Periorbital Cellulitis?

Periorbital cellulitis is most common in children due to sinusitis or trauma. Periorbital cellulitis is commonly caused by the spread of rhinosinusitis. Acute ethmoiditis is the most common rhinosinusitis causing periorbital and orbital cellulitis.  An infection stemming from the ethmoid sinus progresses rapidly because the lamina is very thin between the ethmoid sinus and the periorbital and orbital areas. Sinusitis, hematogenous seeding, direct inoculation of the skin such as with insect bites, periocular or facial trauma, and impetigo are often causes of periorbital cellulitis.

Periorbital Cellulitis Symptoms

  • Unilateral eyelid swelling 
  • Redness of the lid
  • Fever
  • Pain

Diagnosing Periorbital Cellulitis

A clinical examination by an eye doctor is needed to diagnose periorbital cellulitis from orbital cellulitis. Patients with orbital cellulitis present with eyelid swelling and other ocular symptoms such as proptosis, eye pain, decreased vision, and limited eye muscle motility. 

Many patients have a history of sinusitis or upper respiratory infection, trauma, infection from a nearby area, or insect bites.

A computed tomography (CT) scan of the orbits and sinuses can aid in making the diagnosis. If unclear, patients are treated as if they have the diagnosis of orbital cellulitis.

Periorbital Cellulitis Treatment

Most cases of periorbital cellulitis resolve after five to seven days with proper antibiotic treatment. The treatment for periorbital cellulitis should include coverage for the most common bacteria, Staphylococcus aureus, and the Streptococcus species. The current recommendation is Clindamycin or TMP-SMX plus Amoxicillin-clavulanic acid or Cefpodoxime or Cefdinir. 

Treatment also depends on severity and age. Those with more severe diseases or under the age of 1, should be admitted to the hospital.

Sources

  1. Bae C, Bourget D. Periorbital Cellulitis. [Updated 2022 Jul 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.
  2. Baiu I, Melendez E. Periorbital and Orbital Cellulitis. JAMA. 2020 Jan 14;323(2):196. doi: 10.1001/jama.2019.18211. PMID: 31935029.
  3. Malinow I, Powell KR. Periorbital cellulitis. Pediatr Ann. 1993 Apr;22(4):241-6. doi: 10.3928/0090-4481-19930401-08. PMID: 8510991.
  4. Williams KJ, Allen RC. Pediatric orbital and periorbital infections. Curr Opin Ophthalmol. 2019 Sep;30(5):349-355. doi: 10.1097/ICU.0000000000000589. PMID: 31261188.

Related Terms

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Leber Congenital Amaurosis (LCA)

is a congenital retinal dystrophy resulting in nystagmus and significantly reduced vision

Keratotomy

is defined as any surgical cut into the cornea. The cornea is the clear tissue which covers the front part of the eye

Phoropter

is the instrument used by an eye doctor to measure the glasses prescription

Accommodation Disorder

also known as accommodative dysfunction, is any problem with the focusing power of the eye

Geographic Atrophy

is an advanced form of age-related macular degeneration that leads to progressive and irreversible loss of vision

Vitreous Body

or vitreous humor is the clear, gelatinous extracellular matrix (ECM) structure that fills the posterior part of the eye

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