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A-Z Glossary

Table of Contents

Blepharochalasis

Written byDanielle Stoken
Danielle StokenEye Health & Wellness ContributorPittsburgh, PA

Bio

I was so excited when I learned about CorneaCare and am honored to share content, tips and stories about dry eye! I am a certified Health Coach through the Institute for Integrative nutrition so the intersection of nutrition/lifestyle and dry eye disease is one that I am particularly passionate about. Since recently becoming a mom, I care even more about my eye care and self-care and am learning so much through CorneaCare's educational resources.

Get to know me a little better!

Hobby: baking sourdough bread
Food: pasta
Superhero: my dad
Guilty pleasure: cold brew coffee (really, any coffee)
Secret power: serious facial recognition/recollection

Training:

Undergraduate: Carnegie Mellon University
Nutrition training: Institute for Integrative Nutrition

  • Updated May 3, 2022

What is Blepharochalasis?

Blepharochalasis, sometimes referred to as blepharochalasis syndrome, occurs when the eyelids suddenly become inflamed and swell.¹ It’s a rare condition that typically affects the upper eyelids, generally on both sides of the face.¹ Some instances of lower eyelid blepharochalasis exist but are extremely rare.¹ 

A patient with blepharochalasis typically experiences painless eyelid swelling every few months that lasts about 2-3 days.² Flare-ups peak around adolescence and decrease over time, eventually ending as the child reaches adulthood.² 

Because of the low case reports, doctors know little about the causes of blepharochalasis or how to prevent it. Some researchers believe that hormonal changes, such as puberty, can lead to blepharochalasis because the disease affects adolescents.² There are no widely available treatments for blepharochalasis that research has proven effective.²

Key Takeaways

  • Blepharochalasis is a painless eye condition that causes sudden swelling of the eyelid tissues. 
  • The causes of blepharochalasis are unknown, and there are currently no treatments that have been effective in reducing swelling.
  • Complications can occur due to the eyelid skin and tissues stretching, often requiring surgery.

Understanding Blepharochalasis

Blepharochalasis is a rare disorder that begins in childhood and peaks in adolescents.² Although the condition itself does not cause pain or vision loss, recurrent attacks can cause eyelid stretching and drooping that can interfere with eyesight.² Some, but not all, patients experience erythema (redness) on and around the eyelid.¹

Some patients experience attacks 3-4 times a year for 7-10 years.³

The underlying cause of blepharochalasis is unknown. Some research points to hormones, crying, bee stings, stress, allergies, and upper respiratory conditions as triggers of blepharochalasis.¹

Diagnosing Blepharochalasis

Diagnosing Blepharochalasis is Difficult for eye doctors. 

For one, there are no lab tests available for doctors to run.¹ Secondly, symptoms can present as other eye conditions such as allergic conjunctivitis (eye allergies), styes, floppy eyelid syndrome, angioedema (abrupt swelling of the eyes and lips), lacrimal gland tumors, thyroid eye disease and chalazion.³ An eye doctor will perform a comprehensive patient history and examination to rule out differential diagnosis and determine if blepharochalasis is causing the eyelid to swell.³ 

Complications of Blepharochalasis

The constant stretching of the affected eyelid skin can lead to complications that may require surgical interventions.² 

The orbital fat around the eye can prolapse (protrude outward).² Eyelid edema (swelling) and wrinkling due to stretching of the elastic fibers, can make patients with blepharochalasis appear older than they are.² Eye doctors typically look for severely thin skin on and around the eyelid, almost resembling “cigarette paper.”¹

Because the levator aponeurosis (fascial tissue that connects the levator muscle to the connective tissue around the eyelids) stretches during attacks, ptosis can occur. Ptosis is when the eyelids droop over the eye and may interfere with vision.⁴ This stretching can also cause the lacrimal glands (needed for tear production) to prolapse.³ Lacrimal gland prolapse can lead to dry eye symptoms.

Medical Interventions for Blepharochalasis

While there are no reliable treatments for blepharochalasis, some findings suggest using steroids may help reduce symptoms but only in a few cases.³ Oral antihistamines, antibiotics and anti-inflammatory medications do not seem to make a difference in reducing swelling.¹

Surgery may be necessary to repair the damage that occurs because of recurrent attacks.³ 

An eye doctor should perform surgery only when attacks have been at bay for six months or more to reduce the chance of further inflammation and complications.¹

Depending on the severity of complications, doctors can perform eyelid tightening, fat grafting to repair fat atrophy,  blepharoplasty (replacing the eyelid crease) and other reconstructive surgeries to repair damaged tissues and muscles.¹ 

Unfortunately, surgery may not prevent blepharochalasis from recurring. It can lead to overcorrection in some cases where surgeons pull the eyelid skin too tightly or replace it in an unnatural position, which leads to dry eyes and other complications¹

Bibliography

  1. Silkiss, Rona Z. “Blepharochalasis Syndrome – EyeWiki.” EyeWiki, https://eyewiki.org/Blepharochalasis_Syndrome. Accessed 13 April 2022.
  2. Haile, Meron, et al. “Blepharochalasis Syndrome.” American Academy of Ophthalmology, https://www.aao.org/eyenet/article/blepharochalasis-syndrome-2. Accessed 13 April 2022.
  3. Patel, Bhupendra CK. “Blepharochalasis Syndrome – StatPearls.” NCBI, 13 January 2022, https://www.ncbi.nlm.nih.gov/books/NBK560620/. Accessed 13 April 2022.
  4. Salmon, MD, John F. “Eyelids.” Scient Direct, 2020, https://www.sciencedirect.com/topics/medicine-and-dentistry/blepharochalasis

Related Terms

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Epiretinal Membrane

is fibrous tissue (scar tissue) that forms on the top of the retina.

Anterior Chamber

is located between the iris and the innermost corneal surface. It is filled with fluid called aqueous humor.

Dacryostenosis

is inflammation of the nasolacrimal duct (tear sac), mainly due to poor tear drainage.

Canaliculitis

is a disease of the lacrimal canaliculus, which is a small duct in the eyelid.

20/20 Vision

is a term used to describe good visual acuity (clarity) when measured from about 20 feet away.

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