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Complications of Dry Eye Disease

  • Last updated November 8, 2022

5 min read

Jovi Boparai MD Profile Picture
Written byJovi Boparai, MD
J. David Stephens, MD Amanda C. Kahn, MD
Reviewed by J. David Stephens, MD Amanda C. Kahn, MD
Jovi Boparai MD Profile Picture
Jovi Boparai, MDCo-founder & CEO of CorneaCarePhiladelphia, PA

Bio

Dry eye disease is tough! I get it. I have struggled with dry eyes for several years from contact lens use, and from spending countless hours looking at computer screens. In college, my dry eyes got so bad that I couldn’t wear contact lenses, because of a constant “foreign body sensation” when I had them in. I had to stop reading every 30 minutes because my eyes would start to burn and my vision would get blurry. I tried a plethora of treatments and nothing seemed to work. Dry eye disease was not only impacting my eyes, but also my emotional wellbeing. It was preventing me from enjoying life, and getting in the way of my professional training. I felt overwhelmed, frustrated and hopeless.

It was only when I realized that my dry eyes were linked to my lifestyle, environment and overall health did things start to make sense. I noticed that on days when I spent less time on the computer, my eyes felt better. My symptoms would flare when it was windy, or when there was low humidity. I knew that if I wanted to get ahead of my dry eyes, I needed to not only treat my eyes, but to also address my lifestyle. I started a consistent regimen of artificial tears and eyelid hygiene. I switched from monthly contact lenses to daily contact lenses. I started taking scheduled breaks from looking at a computer. I ate a healthier diet focused on anti-inflammatory/antioxidants foods, and I bought a humidifier for my room. In the beginning doing all this seemed impossible, but over time it became part of my usual routine. Not only did my eyes feel better, but I was overall healthier and happier! Turns out what is good for my eyes, was also good for my mind and body. I carried this lesson with me as I started my career to become an ophthalmologist and ophthalmic surgeon.

Because of my personal journey and professional training, I believe dry eye treatment starts by listening to and empowering the patient. I listen for the struggles and cue in on their strengths, while picking up on their lifestyle. Only then do we together start building a treatment plan that incorporates good eye hygiene with small, but impactful lifestyle changes. Our sight is our most important sense, and it is intimately linked to our very being. I want dry eye patients to not only get their dry eyes under control, but to also enjoy good mental and physical health, and live a fulfilling life. What is good for the eyes should also strengthen the mind and fortify the body!

Get to know me a little better!

Hobby: vintage watches
Food: peanut butter
Superhero: Superman
Guilty pleasure: desserts
Secret power: has never had a headache

Training:

Undergraduate: University of Pittsburgh Honors College
Medical school: Weill Cornell Medicine
Ophthalmology residency: Wills Eye Hospital.

J. David Stephens, MD
J. David Stephens, MDOphthalmic SurgeonFort Myers, Fl

Bio

Dr. Stephens is a fellowship trained cornea specialist with extensive expertise in ophthalmology. By combining his clinical and surgical skills with strong relationships, Dr. Stephens is able to provide excellent care tailored to his patients’ specific needs. Through his clinical practice, Dr. Stephens has come to appreciate the multifactorial nature of dry eye disease, and how it can be a byproduct of a patient’s ocular and medical history, environment and lifestyle. He continually strives to provide personalized care, and believes that dry eye treatment needs to address both the physical and emotional needs of the patient.

Get to know Dr. Stephens a little better!

Hobby: ping pong
Favorite food: tex mex
Superhero: Deadpool
Guilty pleasure: sour candy
Greatest weakness: instantly sunburns
Secret power: free throw shooting

Training:

Medical school: University of Oklahoma
Ophthalmology residency: Wills Eye Hospital
Cornea fellowship: Vance Thompson Vision

Amanda C. Kahn, MD
Amanda C. Kahn, MDPrimary Care PhysicianPhiladelphia, PA

Bio

Dr. Kahn is a primary care physician who is passionate about delivering comprehensive, personalized care to her patients. Being at the frontline of healthcare, Dr. Kahn takes care of a diverse patient population. Many of her patients endorse dry eye symptoms, and simply telling them to use artificial tears does not solve the problem. Dr. Kahn has come to appreciate the multifaceted nature of dry eye disease, and how a treatment plan needs to address eye hygiene, along with lifestyle modifications. As a primary care physician, she believes that what is good for the eyes should also be good for the mind and body.

Get to know Dr. Kahn a little better!

Hobby: swimming
Favorite food: brie
Superhero: Jean Grey
Guilty pleasure: dark chocolate
Greatest weakness: Instagram
Secret power: cooking

Training:

Undergraduate: Columbia University
Medical school: Weill Cornell Medicine
Primary care residency: Thomas Jefferson University Hospital

Complications of dry eye disease

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Table of Contents

Key Points

  • Dry eye disease can lead to a significant reduction in work productivity.
  • People who have dry eyes are 2-3 times more likely to have depression and anxiety.
  • The typical dry eye patient can spend thousands of dollars a year on dry eye treatment.
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Keywords 

Anxiety, depression, out-of-pocket costs, surgery, work productivity

Taking the First Step

As we’ve stressed before, dry eye disease (DED) is not just about dry eyes. In addition to your eye health, it negatively affects your physical and emotional well-being and decreases your quality of life.1 Patients with DED are at risk for various eye complications, including dissatisfaction with surgery and increased risk for developing other eye problems. Patients with DED typically feel frustration and hopelessness, leading to anxiety and depression. They may also experience decreased work productivity. A typical patient can spend almost a year self-treating and upwards of $2000 a year on the treatment of dry eyes. 

In this article, we will cover how DED can impact a multitude of things in your life. We do a deeper dive into each of these topics in subsequent articles.

The Impact of Dry Eye Disease On Ocular Health

DED is also known as dry eye syndrome, keratoconjunctivitis sicca and ocular surface disease. DED can lead to several direct and indirect complications with your eyes.2 In addition to symptoms, DED can predispose you to get abrasions (scratches) of the cornea, or lead to irregular healing of corneal tissue. DED can also lead to conjunctivitis by damaging the conjunctiva (a thin membrane that lines the inner part of your eyelids and covers the white part of your eye, the sclera). DED may lead to dissatisfaction after any eye surgery. For example, with cataract surgery, DED can negatively impact pre-operative planning and may lead to poor visual outcomes after surgery.

Dry eye disease and ocular health

Having DED makes it difficult to treat other eye conditions. For example, glaucoma eye drops can worsen pre-existing DED. This is because most eye drops contain benzalkonium chloride (BAK), a preservative that prolongs the shelf-life of eye drops, but can be toxic to the ocular surfaces, including both the cornea and conjunctiva. Having DED may also prevent you from wearing contact lenses or from having refractive surgery (LASIK), both of which can worsen dry eye symptoms. 

While DED does not directly lead to vision loss, it certainly increases your risk for developing vision-threatening conditions.

If left untreated, DED can cause permanent damage to your ocular surface. For example, if you have damage to the surface of the eye from DED, you are at a higher risk for developing corneal ulcers (eye infections). Even when well treated, such infections can leave a scar, leading to decreased visual acuity and visual function, and causing a marked decrease in vision-related quality of life. Luckily, initiating treatment early can help reverse some, if not all, of the ocular surface damage from DED.

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The Impact of Dry Eye Disease On General Health

In addition to eye care, you may have to consider DED when considering treatment options for your overall health care. Developing symptoms of dry eye is a notable side effect of several oral medications like antihistamines, antidepressants, birth control pills, diuretics, decongestants, beta blockers, chemotherapy, and hormone replacement therapy.

Autoimmune conditions, such as Sjögren’s syndrome, rheumatoid arthritis and lupus, are important risk factors for DED. Sjögren’s leads to inflammation of your lacrimal gland, causing decreased tear production and an inadequate tear film, known as aqueous deficient DED. In addition to not producing enough tears, Sjögren’s can also affect your salivary glands, leading to dry mouth. Patients with pre-existing autoimmune conditions may have a higher prevalence of chronic dry eye. In addition to artificial tears and eyelid hygiene, these patients may require topical prescriptions (cyclosporines and lifitegrast) or procedures, such as punctal plugs to block the tear ducts so eye drops stay longer in your tear film.

Learn more about dry eye treatments here.

Dry eye disease and general health

The presence of DED adds to the burden of systemic conditions, meaning you have to take care of both the general health problem and the dry eye symptoms. For example, the hormonal changes during menopause can lead to several health issues, including DED. Menopause and the associated body changes can be taxing on the mind and body. Now throw DED into the mix, and you create a very challenging situation for patients. Rosacea leads to skin changes on your face, and predisposes you to evaporative DED (rapid tear evaporation) by causing meibomian gland dysfunction (MGD) and blepharitis. Cancer and chemotherapy is associated with DED. Having to worry about concurrently managing dry eye symptoms and the treatment of cancer can be immensely difficult.

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Psychological Impact of Dry Eye Disease

There is a well-documented link between DED and emotional health.3 We all get dry eyes once in a while; maybe after working on a computer for several hours, or watching TV for a long time. Most of us experience these symptoms intermittently, but a DED patient experiences them constantly. This has a significant impact on your daily activities and daily life overall. The constant grittiness, dryness, burning, foreign body sensation, light sensitivity, visual impairment with blurred vision and decreased visual function leave DED patients feeling hopeless and frustrated. The rates of depression and anxiety are 2-3 times higher in dry eye patients, resulting in decreased quality of life.4

Depression and anxiety are 2-3 times higher in dry eye patients

Social Impact of Dry Eye Disease

DED can make work and social life very difficult.5 Think about it. We spend most of our working life interfacing with digital monitors, including computers, smartphones and projectors. As you can imagine, the COVID-19 pandemic has made us more reliant on digital screens than ever before. All these smart devices can reduce your blinking significantly, leading to dry eye symptoms, and decreased work productivity.

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When you have DED, you may feel anxious and nervous about going out with friends, especially if your friends want to do something outdoors, or watch sports on TV, or go to the movies. The common environmental factors that can worsen symptoms of dry eye include low humidity, high wind, intense sunlight, and air pollution. All of these things can worsen your dry eye symptoms, leaving your friends wondering why you cannot stop blinking or wiping your eyes, or why you are afraid to go outside. Unfortunately, your friends and family will likely not understand the extent to which DED is affecting you and your quality of life.6

Financial Impact of Dry Eye Disease

A typical patient will spend anywhere from $750 – $2,200 per year on over-the-counter treatment of dry eye, such as lubrication (artificial tears and other eye drops), eyelid hygiene (eyelid wipes and warm compresses), gels, ointments, and oral supplements (omega-3 fatty acids).7 Don’t forget about lifestyle modification costs like humidifiers and air purifiers.

You may also decide to pursue costly out-of-pocket procedures to treat severe dry eye. The range for in-office procedures for dry eye is anywhere from $500 – $1500 out of pocket. Not to mention the co-pays for prescription medications and for seeing eye doctors (ophthalmologists and optometrists). Your insurance may cover your prescriptions and office visits, but you will still be on the hook for co-pays. The costs can really add up!8

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Putting It All Together

We are not sugar-coating it; DED can impact you on so many levels that it gets difficult to function. If you have DED, this “Why it matters” section will resonate with you, because you live it daily. While disappointing, we regretfully admit that there are no diagnostic tests or questionnaires in ophthalmology or optometry that can truly capture your experience with DED. This is why we want to hear from you, and empower you to take control of your DED.

What’s Next

Lets see how your lifestyle impacts dry eye disease.

Bibliography

  1. Tear Film & Ocular Surface Society. Dry Eye Workshop II Report. Ocular Surface Journal, 2017. TFOS DEWS II Report, http://www.tfosdewsreport.org/.
  2. Higuera, Valencia. “Untreated Chronic Dry Eye Complications and Risks.” Healthline, 2019, https://www.healthline.com/health/dry-eye/untreated-complications-risks. Accessed 14 July 2021.
  3. RO Staff. “Feeling Stressed? Dry Eye Could Be Next.” Review of Optometry, 2019, https://www.reviewofoptometry.com/news/article/feeling-stressed-dry-eye-could-be-next. Accessed 8 August 2021.
  4. Vaart, Robert VD, et al. “The association between dry eye disease and depression and anxiety in a large population-based study.” American Journal of Ophthalmology, vol. 159, no. 3, 2015, pp. 470-474. American Journal of Ophthalmology, https://www.ajo.com/article/S0002-9394(14)00769-7/fulltext.
  5. Nichols, Kelly K., et al. “Impact of Dry Eye Disease on Work Productivity, and Patients’ Satisfaction With Over-the-Counter Dry Eye Treatments.” Investigative Ophthalmology and Visual Science, vol. 57, no. 7, 2016, pp. 2975-2982. ARVO Journals, https://iovs.arvojournals.org/article.aspx?articleid=2527938.
  6. Sayegh, Rony R., et al. “Ocular Discomfort and Quality of Life Among Patients in the Dry Eye Assessment and Management Study.” Cornea, vol. 40, no. 7, 2021, pp. 869-876. Wolters Kluwer, https://journals.lww.com/corneajrnl/Abstract/2021/07000/Ocular_Discomfort_and_Quality_of_Life_Among.9.aspx.
  7. Chan, Clara, et al. “Economic burden and loss of quality of life from dry eye disease in Canada.” BMJ Open Ophthalmology, 2021. BMJ, https://bmjophth.bmj.com/content/bmjophth/6/1/e000709.full.pdf
  8. Healio. “The Economic Burden of Dry Eye Disease.” Healio, 2011, https://www.healio.com/news/ophthalmology/20120331/the-economic-burden-of-dry-eye-disease. Accessed 14 July 2021.

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